Location
Comstock Memorial Union, MSUM
Document Type
Poster
Event Website
https://www.mnstate.edu/sac/
Description
Aspergillus fumigatus is a commonly inhaled respiratory fungal pathogen and an allergen found in flooded indoor environments, household dust, soil, and plant matter. Inhalation of A. fumigatus poses a threat to weakened immune systems due to the potential of infection in the lungs or sinuses which can spread to other areas of the body. The mouse genome is 99% similar to the human genome, and therefore they serve effectively in modeling the effects of inhaled A. fumigatus. A comprehensive literature search of antibody production in mice in response to A. fumigatus inhalation was conducted utilizing PubMed and the search terms of A. fumigatus, mice, inhalation, and antibodies. We considered all forty-one articles to answer seven questions. Our analysis questioned the types of antibodies elicited in response to A. fumigatus, the differences between antibody titers in the serum, the type of insult (dry fungal spores vs. suspension vs. protein allergen mix) utilized, the route of exposure, if male and female results were analyzed separately, and the number of challenges and time points used in each study. We found that 48.2% of the studies measured IgE levels while IgG levels were reported in 28.6% of the studies. It is important to know and understand the antibodies which are most often elicited in response to A. fumigatus in mice, since mice are one of the most common models for A. fumigatus exposure. Ultimately, this data will help inform the optimization of mouse procedures for A. fumigatus exposure, that are critical for developing treatment and diagnostic options for humans.
Literature Review: Antibody Production in Mice in Response to Aspergillus fumigatus Inhalation
Comstock Memorial Union, MSUM
Aspergillus fumigatus is a commonly inhaled respiratory fungal pathogen and an allergen found in flooded indoor environments, household dust, soil, and plant matter. Inhalation of A. fumigatus poses a threat to weakened immune systems due to the potential of infection in the lungs or sinuses which can spread to other areas of the body. The mouse genome is 99% similar to the human genome, and therefore they serve effectively in modeling the effects of inhaled A. fumigatus. A comprehensive literature search of antibody production in mice in response to A. fumigatus inhalation was conducted utilizing PubMed and the search terms of A. fumigatus, mice, inhalation, and antibodies. We considered all forty-one articles to answer seven questions. Our analysis questioned the types of antibodies elicited in response to A. fumigatus, the differences between antibody titers in the serum, the type of insult (dry fungal spores vs. suspension vs. protein allergen mix) utilized, the route of exposure, if male and female results were analyzed separately, and the number of challenges and time points used in each study. We found that 48.2% of the studies measured IgE levels while IgG levels were reported in 28.6% of the studies. It is important to know and understand the antibodies which are most often elicited in response to A. fumigatus in mice, since mice are one of the most common models for A. fumigatus exposure. Ultimately, this data will help inform the optimization of mouse procedures for A. fumigatus exposure, that are critical for developing treatment and diagnostic options for humans.
https://red.mnstate.edu/sac/2022/cshe/3